{"id":2516,"date":"2017-11-09T16:39:30","date_gmt":"2017-11-09T21:39:30","guid":{"rendered":"http:\/\/www.cathybiase.com\/?p=2516"},"modified":"2017-11-09T16:39:30","modified_gmt":"2017-11-09T21:39:30","slug":"gut-health-influences-response-immunotherapy","status":"publish","type":"post","link":"https:\/\/cathybiase.com\/index.php\/2017\/11\/09\/gut-health-influences-response-immunotherapy\/","title":{"rendered":"Gut Health Influences Response to Immunotherapy"},"content":{"rendered":"

Cancer cells develop the ability to avoid detection by our immune system. This understanding has lead to the development of a class of therapy, called immunotherapy, that strives to engage aspects of one’s own immune system to gain or regain the ability to detect and destroy cancer.<\/p>\n

Our understanding of the microbiome and its impact on our immune system is ever evolving but what we can land upon is that there is a symbiotic relationship between our microbiota and our immune system. A healthy, diverse microbiota positively influences our immune system.<\/p>\n

With this understanding, it is not too surprising that two recent studies have found a connection between gut health and the outcome of certain cancer immunotherapies.<\/p>\n

In the first study entitled Gut microbiome modulates response to anti\u2013PD-1 immunotherapy in melanoma patients<\/a> scientists examined the oral and gut microbiome of melanoma patients undergoing a therapy called Anti-PD-1 immunotherapy.\u00a0 As stated in the study,<\/p>\n

\u201cSignificant differences were observed in the diversity and composition of the patient gut microbiome of responders (to the treatment) versus non-responders (to the treatment)\u2026Immune profiling suggested enhanced systemic and anti-tumor immunity in responding patients with a favorable gut microbiome\u201d<\/em><\/p>\n

The second study entitled Gut microbiome influences efficacy of PD-1\u2013based immunotherapy against epithelial tumors<\/a>\u00a0found evidence suggesting that antibiotics taken in close proximation of treatment depleted microbiome diversity resulting in less favourable results than those with a more diverse microbiome.<\/p>\n

These studies lend support to that adage that all roads to good health lead to the gut.\u00a0 More importantly they\u00a0demonstrate the importance of fostering a healthy microbiome.\u00a0 Cancer protocols must lend support to promoting gut health.<\/strong><\/em>\u00a0 In general terms this would suggest a diet that incorporates fermented foods, one that is rich in fruits and vegetables, high in fiberous foods and one that is devoid of all processed foods.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Cancer cells develop the ability to avoid detection by our immune system. This understanding has lead to the development of a class of therapy, called immunotherapy, that strives to engage … Continue reading Gut Health Influences Response to Immunotherapy<\/span><\/a><\/p>\n","protected":false},"author":6,"featured_media":2517,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27],"tags":[64,350,351,193],"class_list":["post-2516","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer-coaching","tag-cancer","tag-diversity","tag-immunotherapy","tag-microbiome"],"yoast_head":"\nGut Health Influences Response to Immunotherapy - Cathy Biase<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cathybiase.com\/index.php\/2017\/11\/09\/gut-health-influences-response-immunotherapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gut Health Influences Response to Immunotherapy - Cathy Biase\" \/>\n<meta property=\"og:description\" content=\"Cancer cells develop the ability to avoid detection by our immune system. 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